Publications by authors named "E Cicek"
Background: The purpose of this study was to examine the reliability and validity of the Turkish version of the Nursing Activities Score.
Methods: To validate the Turkish version of the Nursing Activities Score, a sample comprising 30 adult intensive care patients and 30 nurses was employed. After a pilot study, the internal consistency, Cronbach's alpha coefficient, was found to be p = 0.
Comprehensive proteomics analysis reveals novel Nek2-regulated pathways and therapeutic targets in cancer.
Biochem Biophys Res Commun
November 2024
Article Synopsis
- Nek2 is a mitotic kinase often overexpressed in cancers, influencing cell cycle processes, proliferation, and drug resistance, making it a target for cancer therapy.
- A global proteomics analysis identified 1815 proteins, with 358 showing significant changes related to Nek2 modulation in cancer cells.
- The study found a strong link between Nek2 levels and two proteins, KIF20B and RRM1, suggesting they could be effective therapeutic targets in conjunction with Nek2 inhibitors for better cancer treatment outcomes.
The Association Between Oxidative Stress and Sperm Parameters in Patients with Acromegaly.
Exp Clin Endocrinol Diabetes
September 2024
Article Synopsis
- Spermatozoa are vulnerable to damage from oxidative radicals, particularly in patients with acromegaly, prompting an investigation into this relationship.
- The study assessed oxidant and antioxidant levels in the semen and serum of 22 acromegalic patients versus 14 healthy controls, revealing significantly elevated oxidant levels in the patients' semen.
- Findings indicated a negative correlation between total oxidant status and key sperm parameters, suggesting that increased oxidative stress may negatively impact semen quality in individuals with acromegaly.
Objective: The aim of this study was to determine the incidence of pressure ulcers (PUs) in patients treated for acute ischaemic stroke (AIS) and to evaluate comorbid/confounding factors.
Method: The study included patients treated for AIS who were divided into three treatment groups: those receiving intravenous tissue plasminogen activator therapy (tPA); patients receiving mechanical thrombectomy (MT); and those receiving both tPA and MT. PUs were classified according to the international classification system and factors that may influence their development were investigated.
Unlike normal cells, cancer cells frequently exhibit supernumerary centrosomes, leading to formation of multipolar spindles that can trigger cell death. Nevertheless, cancer cells with supernumerary centrosomes escape the deadly consequences of unequal segregation of genomic material by coalescing their centrosomes into two poles. This unique trait of cancer cells presents a promising target for cancer therapy, focusing on selectively attacking cells with supernumerary centrosomes.
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