Publications by authors named "E Chirinos"
Network plasticity in the medial perforant path (MPP) of adult (five to nine months) and aged (18-20 months) urethane-anesthetized male and female Sprague Dawley rats was characterized. Paired pulses probed recurrent networks before and after a moderate tetanic protocol. Adult females exhibited greater EPSP-spike coupling suggesting greater intrinsic excitability than adult males.
View Article and Find Full Text PDFObjectives: To determine the association between mean airway pressure and 90-day mortality in patients with acute respiratory failure requiring mechanical ventilation and to compare the predictive ability of mean airway pressure compared with inspiratory plateau pressure and driving pressure.
Design: Prospective observational cohort.
Setting: Five ICUs in Lima, Peru.
Objectives: Weaning protocols establish readiness-to-wean criteria to determine the opportune moment to conduct a spontaneous breathing trial. Weaning protocols have not been widely adopted or evaluated in ICUs in low- and middle-income countries. We sought to compare clinical outcomes between participants whose weaning trials were retrospectively determined to have been premature, opportune, or delayed based on when they met readiness-to-wean criteria.
View Article and Find Full Text PDFBackground: Clinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the course of MV (ARDS after MV onset) are not well understood. We conducted an observational study in five Peruvian ICUs to characterize differences between ARDS at MV onset and after MV onset and identify risk factors for the development of ARDS after MV onset.
Methods: We consecutively enrolled critically ill patients with acute respiratory failure requiring at least 24 h of mechanical ventilation and followed them prospectively during the first 28 days and compared baseline characteristics and clinical outcomes by ARDS status.
Article Synopsis
- The study examined how sedation levels and the use of certain medications, like benzodiazepines and opioids, affected clinical outcomes in critically ill patients on mechanical ventilation in Lima, Peru.
- The research followed 1,657 patients over 28 days, revealing that deep sedation was linked to significantly higher mortality rates and fewer days without ventilator, ICU, and hospital dependency.
- Additionally, while benzodiazepines were commonly used and associated with increased death risk, haloperidol showed a potential benefit, resulting in lower mortality rates among patients.