DETERMINATION OF ANTIOXIDANT ACTIVITY OF WINES AND WINE'S MAJOR PHENOLIC COMPOUNDS BY ELECTRON SPIN RESONANS, USING SPIN-TRAPS METHOD.

Our results showed, that EPR method using DMPO spin-trapping is characterized with high sensitivity, which enables to define anti oxidative activity of very small concentration of major antioxidants in Georgian and foreign red and white wines and in red wine. It was concluded, that red as well as white wines have very high anti oxidative activities. Herewith it has to be mentioned, that anti oxidative activity of red wine does not always correlate with the total concentration of phenol in it and mostly depends on the concentration of different major antioxidants.

Role of the Free Radicals in Mechanisms of Gallstone Formation: An EPR Study.

The mechanism of gallstone formation is not well understood. Abnormal regulation of hepatic cholesterol, bile acid synthesis or esterification, deposition of cholesterol monohydrate crystals and gall bladder dysfunction are thought to be the principal metabolic aberrations that may cause gallstone formation. One plausible mechanism leading to these abnormalities is the role of free radicals, whose presence can be investigated using Electron Paramagnetic Resonance (EPR).

[KINETICS OF PHOTO-INDUCED FREE RADICALS IN THE HUMAN HAIR CHESTNUT COLOR AFTER SHORT PERIODS OF RED, GREEN, BLUE AND WHITE LIGHT EXPOSURE].

The aim of the study was to investigate the kinetics of photo-induced free radicals in the human hair chestnut color with short-term exposure to visible light in different frequency ranges. Studies carried out on human volunteers aged 17-21 years (n=37). Hairs of volunteers of the study were not treated with dyes and other active cosmetic preparations.

[VISIBLE LIGHT AND HUMAN SKIN (REVIEW)].

Biological effect of a visible light depends on extend of its property to penetrate into the tissues: the greater is a wavelength the more is an effect of a radiation. An impact of a visible light on the skin is evident by wave and quantum effects. Quanta of a visible radiation carry more energy than infrared radiation, although an influence of such radiation on the skin is produced by the light spectrum on the boarder of the ultraviolet and the infrared rays and is manifested by thermal and chemical effects.

Effect of ascorbic acid (vitamin C) on the ESR spectra of the red and black hair: pheomelanin free radicals are not always present in red hair.

Increased incidence of melanoma in the population with red hair is conditioned by synthesis of pheomelanin pigments in the skin and their phototoxic properties. The recent research has shown that free radicals of pheomelanin are produced not only by the influence of UV irradiation, but also in UV-independent pathways of oxidative stress. It has been ascertained, that the color of the hair is not always determinant of the amount of pheolemanin radicals in red hair.