Electrochemical DABCOylation enables challenging aromatic C-H amination.

The selective amination of aromatic C-H bonds is a powerful strategy to access aryl amines, functionalities found in many pharmaceuticals and agrochemicals. Despite advances in the field, a platform for the direct, selective C-H amination of electronically diverse (hetero)arenes, particularly electron-deficient (hetero)arenes, remains an unaddressed fundamental challenge. In addition, many (hetero)arenes present difficulty in common selective pre-functionalization reactions, such as halogenation , or metal-catalyzed borylation and silylation .

Meteorin-like protein plasma levels are associated with worse outcomes in de novo heart failure.

Background And Aims: Meteorin-like protein (Metrnl) has been recently suggested as a new adipokine with protective cardiovascular effects. Its circulating levels in patients seem to be associated with heart failure (HF), although with contradictory results. Our aim was to ascertain whether this adipokine could estimate the prognosis of HF in de novo HF (DNHF) patients.

Enhanced thermogenesis in PAS Kinase-deficient male mice.

PAS domain-containing serine/threonine-protein kinase (PASK) is a nutrient and energy sensor regulated by fasting/refeeding conditions in hypothalamic areas involved in controlling energy balance. In this sense, PASK plays a role in coordinating the activation/inactivation of AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) in response to fasting. PASK deficiency protects against the development of diet-induced obesity.

Sperm recovery from urine in men with retrograde ejaculation.

Introduction: Retrograde ejaculation (RE) consists of the reflux backwards, towards the bladder, of the ejaculate, during the emission phase of ejaculation, causing a total or partial absence of sperm emission, with the consequent diversion of semen into the bladder during the emission phase of ejaculation. Evaluating the ejaculate may not be sufficient for identifying RE in some patients. Hence, the management of infertility may involve the use of invasive methods such as epididymal fluid retrieval or testicular biopsy.

Comparing quantity of marine debris to California horn shark sightings and egg appearances in Redondo Beach, California, USA.

Marine debris such as plastic, metal, and rubber, is a significant source of anthropogenic waste pollution in oceanic waters. Debris continues to be found along Southern California's coastlines and poses serious risks to biodiversity and ecosystem health through entrapment, ingestion, and entanglement. One particular species that drops eggs in the South Bay, particularly in the Palos Verdes peninsula, is the California horn shark (Heterodontus francisci).