Publications by authors named "E Chevret"
Primary cutaneous lymphomas (PCLs) are a heterogeneous group of lymphoproliferative disorders caused by the accumulation of neoplastic T or B lymphocytes in the skin. Sézary syndrome (SS) is an aggressive and rare form of cutaneous T cell lymphoma (CTCL) characterized by an erythroderma and the presence of atypical cerebriform T cells named Sézary cells in skin and blood. Most of the available treatments for SS are not curative, which means there is an urgent need for the development of novel efficient therapies.
View Article and Find Full Text PDFThe syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines are reported here in six steps starting from various halogeno-quinazoline-2,4-(1,3)-diones or substituted anilines. The antiproliferative activities of the products were determined in vitro against a panel of breast (MCF-7 and MDA-MB-231), human adherent cervical (HeLa and SiHa), and ovarian (A2780) cell lines. Disubstituted 6- and 7-phenyl-bis(3-dimethylaminopropyl)aminomethylphenyl-quinazolines , , and displayed the most interesting antiproliferative activities against six human cancer cell lines.
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- Aging is when our bodies slowly lose strength and abilities needed to stay alive and reproduce over time.!
- T-cells, a type of immune cell, change a lot as we get older, especially with things like telomeres and telomerase, which are important for keeping cells healthy.!
- This text reviews how these changes in T-cells relate to health, aging, and diseases, especially cancers linked to short telomeres and telomerase problems.!
Article Synopsis
- * Analysis of 94 CTCL patients revealed that specific genetic variations (SNPs) in the telomerase gene may contribute to the disease's occurrence and progression.
- * Findings suggest that post-transcriptional regulation of telomerase, including alterations in splicing patterns of transcripts, is crucial for CTCL development, indicating a potential target for therapeutic intervention.
Tissue engineering strategies aim at characterizing and at optimizing the cellular component that is combined with biomaterials, for improved tissue regeneration. Here, we present the immunoMap of apical papilla, the native tissue from which SCAPs are derived. We characterized stem cell niches that correspond to a minority population of cells expressing Mesenchymal stromal/Stem Cell (CD90, CD105, CD146) and stemness (SSEA4 and CD49f) markers as well as endothelial cell markers (VWF, CD31).
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