Publications by authors named "E Checinska"
Thirteen healthy postmenopausal volunteers were studied under basal conditions and at intervals (days 1, 5, 10, and 30) after intravaginal placement of a polysiloxane ring impregnated with 400 mg of estradiol. Mean serum estradiol concentrations rose 26-fold with a twofold increase in serum estrone concentrations. Serum delta 4-androstenedione, dehydroepiandrosterone sulfate, and total testosterone did not change, but absolute and percent free testosterone concentrations declined significantly by day 5.
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- The study found a significant decrease in the activity of two glycolytic enzymes, aldolase and pyruvate kinase, in erythrocytes (red blood cells) of men with hypogonadism and in castrated rabbits.
- During testosterone replacement therapy, an increase in both enzyme activities was observed in both groups, although the increase in pyruvate kinase in men was not statistically significant due to a small sample size.
- The authors propose that testosterone affects the activity of glycolytic enzymes in the bone marrow, suggesting that the decreased enzyme activity in men with hypogonadism could impact their red blood cell function, highlighting the importance of long-term testosterone therapy.