Absorption of lincomycin through the respiratory pathways and its influence on alveolar macrophages after aerosol administration to chickens.

A concentration of 250 mg m-3 lincomycin was administered by aerosol to 40 chickens, weighing between 1900 and 2200 g. The birds were killed in groups of five at different intervals after dosing, and the trachea, lungs and blood serum were examined for antibiotic content by bioassay. The antibiotic was present at high levels in the trachea for one to 24 hours, and significant levels were present in the lungs and serum.

[Physicochemical and pharmacokinetic research on Pharmachim's thiabendazole].

Studied was the preparation thiabendazole-Pharmachim (TBZ-Ph), produced by the Economic Corporation "Pharmachim". In some of the experiments TBZ-Ph was comparatively studied with the Merck & Sharp and Dom preparation (TBZ-MShD), Switzerland. It was found that the light absorption maximum of TBZ-Ph was at 302 nm.

[Pharmacokinetic research and the ultrastructural changes in the lungs of white rats after aerosol administration of a high dose of kanamycin sulfate].

Studied is kanamycin sulphate "Pharmachem", substance with activity 750 UI/mg, applied on albino rats in the form of water aerosol. The experiments are carried out in aerosol camera of flow-dynamic type with capacity 450 l at exchange of the air 60 l/min with aerosol apparatus of pneumatic type, for 10 min and staying in the aerosol cloud another 10 min. It is established that the kanamycin sulphate, after aerosol application on albino rats in dose of 50000 UI/m3, passes in the blood and is found out in the serum yet in the first hour (1.

[Pharmacokinetic research on Pharmachem's lincomycin hydrochloride in pigs].

In the experiments lincomycin hydrochloride LMC "F" with activity 820 UI/mg was used. It was established that in pigs, 5% water solution of LMC "F", applied intramuscularly in doses of 5 and 10 mg/kg m. and internally in doses 50 and 100 mg/kg m.

[Toxicological and pharmacokinetic research on lincomycin hydrochloride in broiler chickens and layer hens].

Tested was the activity of linkomycin hydrochloride at the rate of 820 IU/mg. The LD50 of the preparation was found to exceed 12.0 g/kg body mass at intracrop application to broiler birds.