Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in response to neuronal activation, is commonly used to map brain activation or dysfunction. Here we tested the reemerging hypothesis that CO generated by neuronal metabolism contributes to NVC. We combined functional ultrasound and two-photon imaging in the mouse barrel cortex to specifically examine the onsets of local changes in vessel diameter, blood flow dynamics, vascular/perivascular/intracellular pH, and intracellular calcium signals along the vascular arbor in response to a short and strong CO challenge (10 s, 20%) and whisker stimulation.
View Article and Find Full Text PDFWe report a 31-year-old woman who was previously subjected to aortic, mitral, and tricuspid valve replacement in three different surgical episodes. She was admitted to our cardiology section with acute right heart failure symptoms. She was studied by echocardiography, right/left heart catheterization, cardiac CT scan and cardiac magnetic resonance.
View Article and Find Full Text PDFLaser scanning microscopy is widely used to measure blood hemodynamics with line-scans in physiological and pathological vessels. With scans of broken lines, i.e.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
April 2022
An ongoing controversy in brain metabolism is whether increases in neural activity cause a local and rapid decrease in oxygen concentration (i.e., the “initial dip”) preceding functional hyperemia.
View Article and Find Full Text PDFDiameter fluctuations of branches, shoots, or fruits are related to plant transpiration and water potential. In the past, several models have related dendrometric variables and evapotranspiration on a daily scale. However, trunk-branch shrinkage occurs only between dawn and midday, while evapotranspiration occurs most of the day from sunrise to sunset.
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