Publications by authors named "E Catamo"
Article Synopsis
- Type 1 diabetes is an autoimmune condition influenced by genetic factors, primarily related to class II genes, but there is growing interest in the role of class I genes in its development.
- A study involving 115 children and young adults used advanced genetic typing to show that 13% had non-classical haplotypes that increase diabetes risk, differing significantly in immune response and clinical features compared to those with classical haplotypes.
- Findings suggest that the genetic landscape of type 1 diabetes is more complex than previously understood, indicating potential new strategies for prevention and management of the disease.
Article Synopsis
- * The research showed that individuals with high polygenic risk scores have significantly higher blood pressure (almost 17 mmHg more) and over seven times the risk of developing hypertension compared to those with low scores.
- * Incorporating these genetic risk scores into hypertension prediction models improved their accuracy, and excitingly, similar genetic associations were found in a large African-American sample, underscoring the potential of these findings for precision health initiatives.
Diet is an essential element of treating and managing type 1 diabetes (T1D). However, limited research has examined food behaviour in children and adolescents with T1D and their relationship to glycaemic control. This study evaluated food behaviour, metabolic characteristics and their impact on the glycaemic control of children and adolescents with T1D.
View Article and Find Full Text PDFThe HNF1A transcription factor, implicated in the regulation of pancreatic beta cells, as well as in glucose and lipid metabolism, is responsible for type 3 maturity-onset diabetes of the young (MODY3). HNF1A is also involved in increased susceptibility to polygenic forms of diabetes, such as type 2 diabetes (T2D) and gestational diabetes (GD), while its possible role in type 1 diabetes (T1D) is not known. In this study, 277 children and adolescents with T1D and 140 healthy controls were recruited.
View Article and Find Full Text PDFIntroduction: The purpose of this study was to evaluate lipid profile and kidney function in children and adolescents with Type 1 Diabetes.
Methods: This was a retrospective study including 324 children and adolescents with Type 1 Diabetes (48% females, mean age 13.1 ± 3.