Publications by authors named "E Casiglia"
Pulse pressure amplification (PPA) is the brachial-to-aortic pulse pressure ratio and decreases with age and cardiovascular risk factors. This individual-participant meta-analysis of population studies aimed to define an outcome-driven threshold for PPA. Incidence rates and standardized multivariable-adjusted hazard ratios (HRs) of cardiovascular and coronary endpoints associated with PPA, as assessed by the SphygmoCor software, were evaluated in the International Database of Central Arterial Properties for Risk Stratification (n = 5608).
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- - This study analyzed the link between metabolically healthy overweight/obese adults and major cardiovascular events (MACE) using data from 15,904 participants over 11.8 years, focusing on how LDL-cholesterol levels affect this relationship.
- - Among participants younger than 70, being overweight/obese raised the risk of MACE significantly, while older adults had a lower risk despite having high BMI.
- - Including LDL-cholesterol in the definition of healthy metabolism showed that metabolically healthy overweight/obese individuals have no increased risk of MACE compared to normal weight individuals, challenging standard assessments of health risk.
High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been recently postulated. Subjects from the URic acid Right for heArt Health (URRAH) study with carotid ultrasound and without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in the analysis.
View Article and Find Full Text PDFSeveral studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict CV mortality at 5.
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