Publications by authors named "E Carrillo"
Characterizing the epidemiology of circulating respiratory pathogens during the COVID-19 pandemic could clarify the burden of acute respiratory infections and monitor outbreaks of public health and military relevance. The US Department of Defense supported 2 regions for influenza-like illness and severe acute respiratory infections surveillance, one in the Middle East through US Naval Medical Research Unit EURAFCENT, and another in Latin America through US Naval Medical Research Unit SOUTH. During 2020‒2022, coinciding with the COVID-19 pandemic, we collected a total of 16,146 nasopharyngeal and oropharyngeal swab samples from sentinel sites in Jordan (n = 11,305) and Latin America (n = 4,841).
View Article and Find Full Text PDFThyroid hormone binds to specific nuclear receptors, regulating the expression of target genes, with major effects on cardiac function. Triiodothyronine (T3) increases the expression of key proteins related to calcium homeostasis, such as the sarcoplasmic reticulum calcium ATPase pump, but the detailed mechanism of gene regulation by T3 in cardiac voltage-gated calcium (Cav1.2) channels remains incompletely explored.
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- * The study uses advanced techniques to examine the structural differences between GluN2A and GluN2D receptors, linking their unique functions to specific conformational changes in their amino-terminal domains.
- * Findings suggest that changes in one part of the receptor can affect another part, revealing a complex communication system within the receptor that can be influenced by external molecules, enhancing its activity.
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that mediate the majority of excitatory neurotransmission. iGluRs are gated by glutamate, where upon glutamate binding, they open their ion channels to enable cation influx into post-synaptic neurons, initiating signal transduction. The structural mechanism of iGluR gating by glutamate has been extensively studied in the context of positive allosteric modulators (PAMs).
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- Emergency physicians without specialized EMS training often face ethical dilemmas when assessing a patient's decision-making capacity, especially when patients refuse hospital transport.
- A modified Delphi method involving 19 expert physicians was used to reach consensus on best practices for evaluating capacity in these situations.
- Ultimately, the panel established 16 standardized guiding questions and recommendations to enhance the capacity assessment process, with discussions addressing patient concerns and alternative care options.