One-minute dynamic cerebral autoregulation in severe head injury patients and its comparison with static autoregulation. A transcranial Doppler study.

Objective: To compare dynamic and static responses of cerebral blood flow to sudden or slow changes in arterial pressure in severe traumatic brain injury (TBI) patients.

Design: Prospective study.

Patients And Methods: We studied 12 severe TBI patients, age 16-63 years, and median GCS 6.

Cerebral CO2 reactivity in severe head injury. A transcranial Doppler study.

Background: Cerebral circulation is profoundly affected by changes in PaCO2. CO2 manipulation plays a basic role in the management of intracranial hypertension; CO2 reactivity (CO2R) defines the changes in CBF in response to changes in PaCO2. Transcranial Doppler has allowed exploring its effects "on line".

Indomethacin and cerebral autoregulation in severe head injured patients: a transcranial Doppler study.

Objective: To assess the effect of indomethacin on cerebral autoregulation, systemic and cerebral haemodynamics, in severe head trauma patients.

Design: Prospective, controlled clinical trial, with repeated measurements.

Settings: A 12-bed adult general intensive care unit in a third level referral university hospital.

Comparison between two static autoregulation evaluation methods.

Cerebral static autoregulation (AR) was evaluated at bedside in 14 severely head injured patients. 16 investigations were performed. Cerebral perfusion pressure (CPP) was increased by infusing vasopressors during one hour, and registered every 2-5 minutes.

Gastric intramucosal pH and intraluminal PCO2 during weaning from mechanical ventilation.

Objective: To study the value of gastric intramucosal pH and gastric intraluminal PCO2 measurements to predict weaning outcome from mechanical ventilation.

Design: Prospective clinical study.

Setting: Intensive care medicine department of a university hospital.