Publications by authors named "E Canet-Soulas"
Article Synopsis
- Recent research has created normative growth charts for the brain structure of rhesus macaques, filling a gap in understanding nonhuman primate neurodevelopment.
- The study analyzed 1,522 MRI scans from 1,024 macaques to identify developmental patterns in brain volume, cortical thickness, and surface area throughout their lifespan.
- These findings not only highlight key milestones in macaque brain development but also allow for meaningful comparisons to human brain maturation, providing a valuable resource for future neuroscience studies.
Article Synopsis
- Myocardial infarction (MI) causes heart muscle damage due to blocked blood flow, leading to the production of reactive oxygen species and a redox imbalance, with myoglobin playing a key role in this process.
- The study introduces a new imaging method that uses advanced techniques to examine the oxidation-reduction states of myoglobin in heart tissue after MI, revealing how myoglobin's fluorescence can indicate the state of the myocardium.
- Findings show that the spectral properties of myoglobin in infarcted heart tissue correlate with infarct size, suggesting myoglobin's redox state could be a valuable biomarker for assessing MI severity in its early stages.
Non-human primate studies are unique in translational research, especially in neurosciences where neuroimaging approaches are the preferred methods used for cross-species comparative neurosciences. In this regard, neuroimaging database development and sharing are encouraged to increase the number of subjects available to the community, while limiting the number of animals used in research. Here we present a simultaneous positron emission tomography (PET)/magnetic resonance (MR) dataset of 20 Macaca fascicularis images structured according to the Brain Imaging Data Structure standards.
View Article and Find Full Text PDFReperfusion therapies in acute ischemic stroke have demonstrated their efficacy in promoting clinical recovery. However, ischemia/reperfusion injury and related inflammation remain a major challenge in patient clinical management. We evaluated the spatio-temporal evolution of inflammation using sequential clinical [C]PK11195 PET-MRI in a non-human primate (NHP) stroke model mimicking endovascular thrombectomy (EVT) with a neuroprotective cyclosporine A (CsA) treatment.
View Article and Find Full Text PDFMicroglial phagocytosis of apoptotic debris prevents buildup damage of neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse and preclinical monkey models of stroke (macaques and marmosets) by transient occlusion of the medial cerebral artery (tMCAo). By analyzing recently published bulk and single cell RNA sequencing databases, we show that the phagocytosis dysfunction was not explained by transcriptional changes.
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