Publications by authors named "E Cameroni"
Article Synopsis
- - SARS-CoV-2 has evolved to evade current monoclonal antibodies (mAbs), emphasizing the need for more resilient treatments that can neutralize various viral strains.
- - A new human mAb called VIR-7229 has shown the ability to effectively neutralize multiple variants of SARS-CoV-2 and other related viruses, due to its unique targeting of a critical viral region known as the receptor-binding motif (RBM).
- - VIR-7229 demonstrates a high resistance to the emergence of virus escape mutants, making it a promising candidate for future therapies against evolving coronaviruses.
Neutralizing monoclonal antibodies hold great potential for prevention of human immunodeficiency virus (HIV) acquisition. IgG is the most abundant antibody in human serum, has a long half-life, and potent effector functions, making it a prime candidate for an HIV prevention therapeutic. We combined Positron Emission Tomography imaging and fluorescent microscopy of Cu-labeled, photoactivatable-green fluorescent protein HIV (PA-GFP-BaL) and fluorescently labeled HGN194 IgG1 to determine whether intravenously instilled IgG influences viral interaction with mucosal barriers and viral penetration in colorectal tissue 2 h after rectal viral challenge.
View Article and Find Full Text PDFCurrently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of vaccines and therapies remains poorly understood. Here we demonstrate that recently emerged BQ.
View Article and Find Full Text PDFArticle Synopsis
- Chronic hepatitis B is a major global health issue, and co-infection with hepatitis delta virus (HDV) can worsen the disease; researchers are studying a monoclonal antibody (mAb) targeting hepatitis B virus (HBV) surface antigen (HBsAg) for potential treatment.
- The monoclonal antibodies were developed from memory B cells of vaccinated individuals and tested in human liver-chimeric mice to observe their effectiveness against HBV and HDV in various stages of infection.
- The chosen mAb, VIR-3434, showed strong neutralization capabilities against multiple HBV genotypes, significantly reducing virus levels in treated mice and is now being considered for clinical trials in humans with chronic hepatitis B or D.