Publications by authors named "E Camera"
Article Synopsis
- Atopic dermatitis (AD) is a long-lasting skin problem that can get worse when bad bacteria take over the skin.
- Researchers studied skin and bacteria in people with severe AD and compared them to healthy people to see how their skin and bacteria were different.
- They found that healthy skin has a better balance of bacteria, while AD skin shows signs of competition between bacteria and different genetic traits that help them stick around.
Article Synopsis
- - Atopic dermatitis (AD) involves changes in skin barrier lipids and immune system responses, particularly influenced by cytokines IL-4 and IL-13 that activate the JAK/STAT signaling pathway.
- - This study tested tofacitinib, a JAK inhibitor, to understand how Th2 cytokines affect lipid metabolism in 3D skin models, finding that these cytokines decreased certain lipid expressions and altered fatty acid profiles.
- - Co-treatment with tofacitinib reversed many of the lipid metabolism disruptions caused by Th2 cytokines, suggesting that blocking JAK/STAT can help maintain lipid homeostasis in conditions like AD.
17-β-estradiol, involved in mesothelioma pathogenesis, and its precursors were explored as potential biomarkers for the early diagnosis of mesothelioma. Using enzyme-linked immunosorbent assay(ELISA) for 17-β-estradiol and ultra-high performance liquid chromatography/tandem mass spectrometry(UHPLC-MS/MS) for 19 17-β-estradiol precursors, a comprehensive analysis of 20steroid hormones was conducted in the serum of mesothelioma patients(n=67), asbestos-exposed healthy subjects(n=39), and non-asbestos-exposed healthy subjects(n=35). Bioinformatics analysis explored three potential serum biomarkers: 17-β-estradiol, DHEA-S, and androstenedione.
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- - Blood purification, specifically using Seraph-100, shows promise in treating sepsis by improving inflammation and controlling an overactive immune response, with a focus on its binding efficacy to several bacteria.
- - A series of experiments using fluorescence-activated cell sorting (FACS) demonstrated a significant 78.77% reduction in bacterial load within the first 30 minutes of treatment, and different bacterial strains exhibited varying growth rates and affinities.
- - Post-experiment analysis revealed that the Seraph-100 filter captured roughly 50% of the bacteria at the top, with the total bacterial count remaining consistent, thereby confirming its effectiveness in reducing infections during hemoperfusion therapy.