Familial Mediterranean Fever Intertwined With a Diagnosis of Crohn's Disease: A Case Report.

Autoinflammatory diseases are a group of disorders caused by the dysregulation of the innate immune system, leading to episodes of systemic inflammation, with familial Mediterranean fever (FMF) being the most common among them. Other inflammatory disorders have recently been associated with FMF, including inflammatory bowel disease, specifically Crohn's disease (CD). While the gastrointestinal involvement in FMF is not the most typical presentation, both FMF and CD can share clinical features that challenge their diagnosis and treatment.

Design and development of a modular perfusion bioreactor prototype using 3D printing.

This study outlines the conceptual and design framework for a modular bioreactor intended to advance accessibility in tissue engineering by providing an optimal environment for three-dimensional cell growth and differentiation. By integrating 3D printing technology, we propose an innovative and cost-effective approach to bioreactor fabrication streamline the development and customization of tissue engineering applications. While the actual cell cultivation within the bioreactor has yet to be undertaken, preliminary analyses-including rigorous rheological evaluation and computational simulations-validate the bioreactor's potential to maintain a uniform, contamination-free culture environment.

Influence of Baseline Kidney Function on Patient and Kidney Outcomes in Patients with COVID-19: A Multi-National Observational Study.

: Acute kidney injury (AKI) is a common complication of coronavirus disease-19 (COVID-19), but the impact of baseline kidney function and care processes on outcomes is not well understood. We hypothesized that baseline kidney health status may influence courses and outcomes of AKI. : This is a multinational, multicenter, retrospective cohort study.

Systemic Bacillus Calmette-Guérin (BCG) Infection in a Patient With Non-Muscle-Invasive Bladder Cancer: A Case Report.

Intravesical Bacillus Calmette-Guérin (BCG) instillation is a widely used adjuvant therapy for non-muscle-invasive bladder cancer (NMIBC), typically associated with a favorable safety profile. However, severe complications such as systemic BCG infection, though rare, can occur and are potentially life-threatening. Diagnosing systemic BCG infection is challenging due to frequently negative microbiological results.

Extensive Arterial Dissection: A Rare Multivascular Emergency.

Aortic dissection is a life-threatening vascular emergency associated with high morbidity and mortality. Clinical manifestations might include severe chest pain to neurological deficits, depending on the arterial segments involved. Extensive dissections involving multiple aortic segments and branch vessel occlusions, such as the carotid arteries, are rare and pose unique diagnostic and therapeutic challenges.