Publications by authors named "E C Siomou"
: The etiology of type 1 diabetes (T1D) remains an area of active research, with genetic and environmental factors being investigated. This meta-analysis aimed to determine if rotavirus vaccination influences the onset of T1D in children. : Following PRISMA 2020 guidelines, two researchers independently searched multiple databases, including PubMed and Google Scholar, for studies published in English from 2006 to September 2024.
View Article and Find Full Text PDFAnaphylaxis in infancy: An area that needs to be highlighted.
Allergol Immunopathol (Madr)
January 2025
Anaphylaxis, the most severe end of the spectrum of allergic reactions, has shown increasing incidence globally over recent years. This hypersensitivity reaction can occur at any age, including infancy. Recent data, although scarce, show that anaphylaxis is increasingly reported in infancy, with food identified as the leading cause of anaphylaxis cases in this age group.
View Article and Find Full Text PDFArticle Synopsis
- A 5-year-old girl with previously normal health was diagnosed with stage 2 hypertension, which is not common in young children and often connected to other disorders.
- Despite normal findings in physical exams and imaging tests like ultrasound and CT scans, blood tests indicated a high renin level and slightly elevated aldosterone, hinting at a potential renovascular issue.
- A specialized renal scan (DMSA) indicated a blockage in a small artery in her kidney, which was successfully fixed through a procedure known as arteriography, emphasizing the usefulness of a captopril DMSA scan in identifying minor kidney artery problems.
Article Synopsis
- - Monogenic defects of beta cell function cause early-onset diabetes due to mutations in single genes that impact insulin secretion, representing about 5% of pediatric diabetes cases.
- - Over 40 subtypes of monogenic diabetes exist, including frequent types like MODY, and despite being linked to one gene mutation, the clinical symptoms can vary widely, complicating diagnosis.
- - Recent advances in genetic sequencing have improved the diagnosis of monogenic diabetes, which is crucial for appropriate treatment and genetic counseling, as the review aims to illustrate with hypothetical clinical scenarios.
Severe Autoimmune Hemolytic Anemia Following Pneumococcal Vaccination in an Infant With Underlying Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: Report of a Case and Review of the Literature.
Cureus
September 2024
Article Synopsis
- The text discusses a rare case of an infant suffering from both autoimmune hemolytic anemia (AIHA) and glucose-6-phosphate dehydrogenase (G6PD) deficiency, highlighting the unusual occurrence of these two conditions together, particularly in infants.
- It mentions that the infant also had a urinary tract infection caused by Escherichia coli and had received recent pneumococcal vaccination, linking these factors to the development of the conditions.
- The goal of the study is to analyze possible connections between the conditions, examine the role of the vaccine, and review existing literature on these topics.