Publications by authors named "E C Rocha"
Article Synopsis
- Conjugative plasmids like pOXA-48 contribute to the spread and evolution of antimicrobial resistance in bacteria, but can also cause fitness costs to their host.
- Using transcriptomics, researchers found that the acquisition of pOXA-48 by multidrug-resistant enterobacteria leads to both unique and shared changes in gene expression, particularly affecting a chromosomal operon in certain bacteria.
- This crosstalk is mediated by a LysR regulator encoded by the plasmid, which enhances the fitness of K. pneumoniae with pOXA-48, indicating that this mechanism may aid in the spread of carbapenem resistance in clinical environments.
Background: Current literature highlights a gap in precise stroke cost data for Latin America. This study measures the real costs associated with acute ischemic stroke care in Latin America using Time-Driven Activity-Based Costing (TDABC). The findings aim to lay a solid foundation for adopting value-based healthcare (VBHC) strategies in the region.
View Article and Find Full Text PDFElevated free fatty acids and oxidative stress may function as pathogenic factors in endothelial dysfunction that is associated with various cardiovascular complications. In recent work, Feng and colleagues report that activation of a lysosomal Ca channel may be a viable option to alleviate oxidative damage by boosting lysosome biogenesis and mitophagy.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the ophthalmological effects of dry eye disease on the quality of life of COVID-19 survivors who had been hospitalized.
- The evaluation included various tests for dry eye disease and a quality of life questionnaire, with most patients reporting severe or critical COVID-19 symptoms.
- Results showed a significant link between dry eye symptoms and lower quality of life ratings, indicating that those suffering from dry eye experienced worse overall health and well-being.