Therapeutic Effect of Alpha Lipoic Acid in a Rat Preclinical Model of Preeclampsia: Focus on Maternal Signs, Fetal Growth and Placental Function.

Chronic hypertension is a major risk factor for preeclampsia (PE), associated with significant maternal and neonatal morbidity. We previously demonstrated that pregnant stroke-prone spontaneously hypertensive rats (SHRSP) display a spontaneous PE-like phenotype with distinct placental, fetal, and maternal features. Here, we hypothesized that supplementation with alpha lipoic acid (ALA), a potent antioxidant, during early pregnancy could ameliorate the PE phenotype in this model.

Longitudinal Association between Late-Life Depression (LLD) and Frailty: Findings from a Prospective Cohort Study (MiMiCS-FRAIL).

Objectives: The aim of the present study was to investigate whether late-life depression (LLD) is associated with incident frailty over time.

Design: Prospective cohort study, one-year follow-up.

Setting: Geriatric outpatient clinic, Southwestern of Brazil.

The association between cardiovascular risk factors and major cardiovascular diseases decreases with increasing frailty levels in geriatric outpatients.

Background: Frailty marks a process of increasing dysregulation of physiological systems which increases the risk of adverse health outcomes. This study examines the hypothesis that the association between multiple cardiovascular risk factors (CVRF) and cardiovascular diseases (CVD) becomes stronger with increasing frailty severity.

Methods: Cross-sectional analysis of 339 older adults (55.

Prediction of Death with the FRAIL-NH in Institutionalized Older Adults: A Longitudinal Study from a Middle-Income Country.

Background/objectives: Frailty is common in nursing homes. However, few studies reported longitudinal validation for death prediction or cut-off scores with the FRAIL-NH, which is designed to be used in nursing homes. Moreover, no studies came from Latin America, where frailty is highly prevalent.

Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update.

Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects.