Publications by authors named "E C Reisinger"
Recent evidence provides strong support for the safe and effective use of gene therapy in humans with hearing loss. By means of a single local injection of a set of adeno-associated virus (AAV) vectors, hearing was partially restored in several children with neurosensory nonsyndromic autosomal recessive deafness 9 (DFNB9), harboring variants in the OTOF gene. Current research focuses on refining endoscopic and transmastoid injection procedures to reduce risks of side effects, as emerging evidence suggests bidirectional fluid exchanges between the ear and the brain.
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- Schistosoma mansoni, a parasite introduced to the Americas during the slave trade, poses a significant health issue in South America and the Caribbean; this study analyzes three strains from Liberia, Belo Horizonte, and Puerto Rico, revealing notable differences in virulence and interactions with hosts.* -
- Researchers examined the physical characteristics and immunological effects of these strains on laboratory mice, finding variations in worm shape, egg size, and organ damage, with the Puerto Rican strain showing the highest virulence.* -
- The findings highlight the need for tailored public health strategies and treatments based on the varying behaviors and immune responses of S. mansoni strains, offering valuable insights for controlling schistosomiasis in different regions.*
Background: This study aimed to support the end-of-shelf life specification (2.5 × 10 virus particles [vp]) for the standard Ad26.COV2.
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