Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability of maintaining drug-free viral control during subsequent treatment interruptions, for reasons that remain unclear. Using samples from a randomized-controlled human clinical trial evaluating therapeutic HIV-1 vaccines, we here show that early ART commencement is frequently associated with accelerated and efficient selection of genome-intact HIV-1 proviruses in repressive chromatin locations during the first year after treatment initiation. This selection process was unaffected by vaccine-induced HIV-1-specific T cell responses.
View Article and Find Full Text PDFThe rapid diversification of terminology associated with invasion ecology is a known barrier to effective communication and management. These challenges are magnified by the addition of terms and concepts related to climate-induced range-shifting taxa and/or changes to impacts. Further, institutional policies and terminologies for invasive species introduce new ambiguities when considering climate change.
View Article and Find Full Text PDFNontuberculous mycobacteria (NTM) cause skin and lung infections, have high mortality rates, and are resistant to a range of antibiotics and water treatment methods. As NTM reside in environmental reservoirs, they are sensitive to environmental conditions. The suitability of their environmental reservoirs can increase as a result of climate change, subsequently increasing environmental exposure and infection rates.
View Article and Find Full Text PDF