The landscape of recurrent spontaneous abortion registered on clinical trials.gov.

Objective: Recurrent spontaneous abortion (RSA) presents a significant challenge in the field of reproductive medicine, as effective treatments remain limited despite extensive research efforts. A comprehensive understanding of current RSA clinical trials is essential for enhancing trial design and identifying existing research gaps. The aim of this study is to characterize RSA related clinical trials registered on Clinical Trials.

Under-Recognized Medication Loss With the Administration of Small-Volume Intermittent Infusions.

Most antibiotics administered via intermittent IV infusion are diluted in 50 to 100 ml of diluent. The primary infusion set for the BD Alaris pumps can hold 25 ml of volume in its tubing, potentially contributing up to a 50% drug loss if residual volume is present after administration is complete. In the case of antibiotics, this may lead to significant underdosing, potentially contributing to reduced therapeutic response and emergence of antimicrobial resistance.

Engineering Surface-Adaptive Metal-Organic Framework Armor to Promote Infected Wound Healing.

Metal-organic frameworks (MOFs) hold enormous promise for treating bacterial infections to circumvent the threat of antibiotic resistance. However, positioning MOFs on wound dressings is hindered and remains a significant challenge. Herein, a facile heterointerfacial engineering strategy was developed to tailor the "MOF armor" that adaptively weaponized the poly(ε-caprolactone) electrospun dressing with excellent bacteria-killing efficacy.

Baihui-Penetrating-Qubin Acupuncture Attenuates Neurological Deficits Through SIRT1/FOXO1 Reducing Oxidative Stress and Neuronal Apoptosis in Intracerebral Hemorrhage Rats.

Background: Intracerebral hemorrhage (ICH) is a significant global disease with high mortality and disability. As of now, there is no effective therapy available. Oxidative stress and neuronal apoptosis play essential roles in ICH, determining neuronal survival.

Molecularly Imprinted Nanozymes with Substrate Specificity: Current Strategies and Future Direction.

Molecular imprinting technology (MIT) stands out for its exceptional simplicity and customization capabilities and has been widely employed in creating artificial antibodies that can precisely recognize and efficiently capture target molecules. Concurrently, nanozymes have emerged as promising enzyme mimics in the biomedical field, characterized by their remarkable stability, ease of production scalability, robust catalytic activity, and high tunability. Drawing inspiration from natural enzymes, molecularly imprinted nanozymes combine the unique benefits of both MIT and nanozymes, thereby conferring biomimetic catalysts with substrate specificity and catalytic selectivity.