Publications by authors named "E C Keung"
Malignant peripheral nerve sheath tumor (MPNST) development is characterized by an altered DNA methylation landscape, which presents a promising area for developing MPNST-specific biomarkers for screening patients with NF1. Genome-wide DNA methylation profiling of a cohort of 13 patients with MPNST (29 samples of tumor and adjacent neurofibroma tissues) and of NF1-MPNST cell lines was performed to identify and validate candidate MPNST-specific CpG sites (CpGs). A logistic regression prediction model was constructed to select MPNST-specific CpGs distinct from adjacent neurofibromas and normal tissues.
View Article and Find Full Text PDFBackground: The course of subclinical gastrointestinal stromal tumors (GISTs) is variable. The management of small GISTs is not well-defined.
Methods: Records of patients presenting with small GISTs with documented follow-up appointment at our institution between 2016 and 2022 were identified and reviewed.
Background: Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT-STS; ClinicalTrials.gov identifier NCT03819985) investigated a radiobiologically equivalent, moderately hypofractionated course of preoperative radiotherapy (RT) 15 × 2.85 Gy in patients with soft tissue sarcoma (STS).
View Article and Find Full Text PDFArticle Synopsis
- Atypical intradermal smooth muscle neoplasm, or cutaneous leiomyosarcoma, is a rare skin tumor that grows slowly and usually isn't very aggressive.
- A study looked at 95 patients with this tumor from 2002 to 2021, mostly men around 58 years old, with most tumors appearing as painless lumps on the legs or arms.
- After treatment, the majority of patients (96%) stayed free of the disease for five years, showing that the outcomes were mostly good.
Article Synopsis
- Treatment options for recurrent or metastatic soft-tissue sarcoma (STS) are limited after initial therapies, which is where percutaneous cryoablation could serve as a minimally invasive alternative for local control.
- A study conducted on 141 patients showed that among 217 cryoablation procedures, the procedure had a low complication rate of 2% and achieved adequate coverage for 82% of tumors.
- The 1-year local progression-free survival rate was 86%, with overall survival rates of 89% at 1 year and 80% at 2 years, suggesting effective outcomes for patients with treatment-refractory STS.