Publications by authors named "E C Downs"
. To identify the most common reasons for consultation to a large specialty breast pathology service at a major institution. To provide insight into the overall challenges in practicing breast pathology.
View Article and Find Full Text PDFThe present investigation aims to examine the role of α-synuclein seed amplification assays for screening Parkinson's disease. Parkinson's disease (PD) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to symptoms such as tremors, bradykinesia, postural instability, dementia, and depression. It is classified as an α-synucleinopathy related to the role of α-synuclein aggregates in neuron degeneration.
View Article and Find Full Text PDFThe aim of this review is to provide the surgical pathologist an overview of lobular lesions, from in situ to invasive carcinoma and the variants, by discussing the epidemiology, clinical characteristics, morphology, immunohistochemistry, known molecular data as well as the treatment recommendations. The recognition of histologic variants of both in situ and invasive lobular carcinoma has expanded the differential diagnosis. Awareness of these different entities is important as treatment recommendations continue to evolve.
View Article and Find Full Text PDFObjective: To determine if mild-moderate hypertriglyceridemia (HTG) is associated with increased development of chronic pancreatitis (CP) or pancreatitis-associated complications in children with acute recurrent or CP.
Study Design: Longitudinal data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2) cohort of children with acute recurrent or CP (n = 559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.
Article Synopsis
- Chronic pancreatitis (CP) increases the likelihood of developing calcium-oxalate kidney stones, and this study focuses on assessing that risk in patients who have undergone total pancreatectomy with islet autotransplantation (TPIAT).
- A retrospective analysis of 629 TPIAT patients found that the risk for kidney stones is significant, with about 29.4% experiencing at least one episode within 15 years post-surgery.
- Key factors associated with increased kidney stone risk included older age, smoking, mild chronic kidney disease, and a history of kidney stones or renal cysts, highlighting the need for clinician awareness and patient counseling on preventative measures.