Structure, conservation and health implications of urban wild meat value chains: A case study of Lagos, Nigeria.

Urban wild meat value chains represent a vital source of protein and livelihood intertwined with culture and complex market systems. Against the backdrop of escalating zoonotic disease concerns linked to wild meat, this research aimed to unravel the structure, governance, species composition and actor characteristics of the wild meat value chain in Lagos, Africa's most populated city. We employed a cross-sectional study design incorporating qualitative and quantitative approaches.

Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates.

Safely achieving therapeutic expression levels with adeno-associated virus (AAV) gene therapy is a significant challenge for treating the large muscle mass in humans. Non-human primates (NHPs) provide a more accurate assessment of the feasibility of achieving an effective and safe dose than rodents. Here, we compared a single systemic administration of AAV5, AAV8, or AAV9 in NHPs, each packaging the C5-12-microdystrophin-FLAG expression cassette.

Feasibility study of a co-designed, evidence-informed and community-based incentive intervention to promote healthy weight and well-being in disadvantaged communities in Scotland.

Objectives: To feasibility test a novel community-based financial incentive scheme to promote healthy weight and well-being.

Design: Single-arm, prospective feasibility study using mixed methods.

Setting: Two communities in Scotland experiencing high levels of disadvantage according to the Scottish Index for Multiple Deprivation (SIMD).

Isolation and Reactivity of Carbene-Stabilized Carbon Disulfide Radical Anions.

The reaction of CAAC-CS betaine (; CAAC = cyclic(alkyl)(amino)carbene) and alkali metal reductants under ambient conditions yields carbene-stabilized carbon disulfide radical anions as crystalline alkali metal salts. The radicals form multinuclear clusters featuring diverse metal sulfide and disulfide interactions, which promote unusual reductive coupling and cyclization of adjacent CS units to CS heterocycles (). The addition of crown ethers to sequesters the alkali cations and facilitates disulfide cleavage to yield stable [CAAC-CS] monomers ( and ).

Rapamycin Enhances CAR-T Control of HIV Replication and Reservoir Elimination in vivo.

Chimeric Antigen Receptor (CAR) T cell therapy shows promise for various diseases. Our studies in humanized mice and non-human primates (NHPs) demonstrate that hematopoietic stem cell (HSCs) modified with anti-HIV CAR achieve lifelong engraftment, providing functional anti-viral CAR-T cells that reduce viral rebound after ART withdrawal. However, T cell exhaustion due to chronic immune activation remains a key obstacle for sustained CAR-T efficacy, necessitating additional measures to achieve functional cure.