Publications by authors named "E C Antoine"
Background: Early access program (formerly cohort Temporary Authorization for Use) was granted for trastuzumab deruxtecan (T-DXd) in France based on DESTINY-Breast01 trial which demonstrated its efficacy and safety in HER2-positive metastatic/unresectable breast cancer after ≥2 anti-HER2-based regimens received at metastatic stage.
Methods: This multicenter real-world early access program included HER2-positive metastatic/unresectable breast patients pretreated with at least two lines of anti-HER2 regimens who received T-DXd 5.4 mg/kg intravenously in monotherapy every 3 weeks.
Throughout history, humans have relied on wood for constructions, tool production or as an energy source. How and to what extent these human activities have impacted plant abundance and composition over a long-term perspective is, however, not well known. To address this knowledge gap, we combined 44,239 precisely dated tree-ring samples from economically and ecologically important tree species (spruce, fir, pine, oak) from historical buildings, and pollen-based plant cover estimates using the REVEALS model from 169 records for a total of 34 1° × 1° grid cells for Central Europe.
View Article and Find Full Text PDFWith more than 60,000 new cases of breast cancer in mainland France in 2023 and 8% of all cancer deaths, breast cancer is the leading cancer in women in terms of incidence and mortality. While the number of new cases has almost doubled in 30 years, the percentage of patients at all stages alive at 5 years (87%) and 10 years (76%) testifies to the major progress made in terms of screening, characterisation and treatment. However, this progress, rapid as it is, needs to be evaluated and integrated into an overall strategy, taking into account the characteristics of the disease (stage and biology), as well as those of the patients being treated.
View Article and Find Full Text PDFArticle Synopsis
- The research focuses on the relationship between soil mechanics and the types of parent rocks found on Mount Bambouto’s southern slopes, specifically under hot and humid conditions.
- Four rock types were identified—trachybasalt, orthogneiss, anatexite, and biotite-hornblende granitoid—which influence the qualities of soils used for construction, such as compressed earth bricks and pavement layers.
- The article suggests methods for selecting suitable soils for construction purposes based on the underlying geology and climate, presenting models for creating masonry units and pavement layers efficiently.
Aim: University students are increasingly affected by mental health problems and need prompt support. The aim of this project was to assess the impact of the mental health first aid (MHFA) training on students' knowledge, attitudes and practices (KAP) concerning mental health in the short, mid and long-term.
Methods: Three studies were conducted in Bordeaux, France, from May 2021 to March 2022.