Publications by authors named "E C Amaral"
Background: There is wide variation in how faculty development (FD) is practiced globally and described in the literature. This scoping review aims to clarify how FD is conceptualised and practiced in health professions education.
Methodology: Using a systematic search strategy, 418 papers, published between 2015-2023, were included for full text review.
Severity of COVID-19 is affected by multiple factors; however, it is not understood how the inflammatory milieu of the lung at the time of SARS-CoV-2 exposure affects the control of viral replication. Here, we demonstrate that immune events in the mouse lung closely preceding SARS-CoV-2 infection affect viral control and identify innate immune pathways that limit viral replication. Pulmonary inflammatory stimuli including resolved, antecedent respiratory infections with or influenza, ongoing pulmonary infection, ovalbumin/alum-induced asthma, or airway administration of TLR ligands and recombinant cytokines all establish an antiviral state in the lung that restricts SARS-CoV-2 replication.
View Article and Find Full Text PDFUnlabelled: Mucormycosis is a life-threatening fungal infection caused by Mucorales fungi, characterized by angioinvasion and tissue necrosis. While it predominantly affects immunocompromised individuals, it can also occur in immunocompetent patients through traumatic inoculations, such as contaminated surgical dressings or injections. We report two cases of cutaneous mucormycosis following the shared use of contaminated intramuscular corticosteroid injections (dexamethasone).
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- Research on visceral leishmaniasis (VL) in mouse models shows that resident Kupffer cells (resKCs) initially support parasite growth in the liver, leading to granuloma formation for controlling the infection.
- In chronic VL, the death and migration of resKCs create an open niche filled by monocyte-derived Kupffer cells (moKCs), indicating a shift in immune response as granulomas evolve.
- The study highlights the importance of macrophage diversity, including both resKC-derived and moKCs, in managing inflammation and immune responses during VL progression.
Multisystem inflammatory syndrome in children (MIS-C) is a rare, potentially fatal complication of SARS-CoV-2 infection. Genetic defects in inflammation-related pathways have been linked to MIS-C, but additional research is needed, especially in diverse ethnic groups. The present study aimed to identify genetic variants underlying MIS-C in Brazilian patients.
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