Publications by authors named "E C Agbo"
Antisense Oligonucleotides in Dyslipidemia Management: A Review of Clinical Trials.
High Blood Press Cardiovasc Prev
October 2024
Article Synopsis
- * This review evaluates the effectiveness and safety of antisense oligonucleotides (ASOs) for treating dyslipidemia and explores their potential in personalized medicine for at-risk patients.
- * Clinical trials suggest that ASOs like Mipomersen and Volanesorsen may be more effective than traditional statins, offering fewer side effects and serving as alternative treatments for patients with inherited lipid disorders.
Article Synopsis
- Breast cancer is a significant health issue for African women, particularly in Ghana, where mortality rates are high and the role of NF-kB (p65) in tumor progression is not well-studied.
- In a study using breast cancer tissues, NF-kB (p65) was found to be expressed in 86.7% of samples, with higher expression linked to worse tumor grades and aggressive cancer types, especially triple-negative breast cancer (TNBC).
- The findings suggest that NF-kB (p65) could be a valuable biomarker for assessing cancer severity and may offer new targets for treatment in breast cancer patients.
Background: Head and neck tumors (HNT) are tumors of the paranasal sinuses, the salivary glands and the upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties and has been implicated in a number of cancers.
Method: The aim of this study was to investigate the expression of RIN1 in head and neck tumors.
Cardiovascular disease (CVD) stands as a global health crisis, with its complex web of conditions, including coronary artery disease, heart failure, hypertension, and stroke, continuing to exact a heavy toll on individuals and healthcare systems worldwide. Despite substantial advances in medical technology and pharmaceutical interventions, CVD remains a formidable adversary, necessitating innovative prevention, management, and rehabilitation approaches. In tracing the historical trajectory of CVD, the narrative reveals the antiquated practices of early 20th-century medicine, marked by extended bed rest as the primary modality for heart-related conditions.
View Article and Find Full Text PDFObjectives: Nrf2/BACH1/HO-1 proteins have been implicated in the development and progression of tumors. However, their clinical relevance in breast cancer remains unclear and understudied. This study evaluated Nrf2/BACH1/HO-1 protein expression and its relationship with age, tumor grade, tumor stage, TNM, ER, PR, HER2, and histologic type.
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