Publications by authors named "E Butturini"
Characteristics of survivors enrolled in the World Trade Center Health Program.
Arch Environ Occup Health
November 2024
The World Trade Center (WTC) Health Program is a limited federal health care program that provides medical monitoring and treatment for WTC-related health conditions to responders and survivors impacted by the terrorist attacks on September 11, 2001.This study described the characteristics of the Program survivor members (who lived, worked, went to school, daycare or adult daycare or present in the New York City Disaster Area of 9/11/2001) to stimulate innovative ideas for improving healthcare services, generate new research interest, and serve as a reference for future research on this population. Administrative and medical claims data collected from the Program start date (07/01/2011) through 2022 were used.
View Article and Find Full Text PDFExtracellular Vesicles (EVs) have been proposed as a promising tool for drug delivery because of their natural ability to cross biological barriers, protect their cargo, and target specific cells. Moreover, EVs are not recognized by the immune system as foreign, reducing the risk of an immune response and enhancing biocompatibility. Herein, we proposed an alternative therapeutic strategy to restore STAT3 signaling exploiting STAT3 loaded EVs.
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- Richter's syndrome (RS) is a severe form of cancer resulting from the evolution of chronic lymphocytic leukemia (CLL) into a high-grade B-cell malignancy, characterized by decreased reliance on BCL-2, a key protein that prevents apoptosis (cell death).
- Studies comparing CLL and RS revealed that RS cells display lower apoptotic priming and may depend on different anti-apoptotic proteins, complicating treatment strategies like using BH3 mimetics that target cell death pathways.
- Transcriptomic analyses showed that as CLL transforms into RS, there is a downregulation of pro-apoptotic factors and changes in mitochondrial structure that contribute to enhanced resistance to apoptosis, making it harder to target RS directly.
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- Breast Cancer is the most common cancer in the world, but current treatments can hurt healthy tissues and sometimes don't work well.
- Researchers are looking into natural plant chemicals and essential oils because they might target tumors safely and effectively.
- Using technology, scientists have found ways to improve the effectiveness of essential oils in fighting breast cancer, making them more stable and easier to use in treatments.
Essential oils (EOs) are mixtures of volatile compounds belonging to several chemical classes derived from aromatic plants using different distillation techniques. Recent studies suggest that the consumption of Mediterranean plants, such as anise and laurel, contributes to improving the lipid and glycemic profile of patients with diabetes mellitus (DM). Hence, the aim of the present study was to investigate the potential anti-inflammatory effect of anise and laurel EOs (AEO and LEO) on endothelial cells isolated from the umbilical cord vein of females with gestational diabetes mellitus (GDM-HUVEC), which is a suitable in vitro model to reproduce the pro-inflammatory phenotype of a diabetic endothelium.
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