Publications by authors named "E Burlacu"
In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show that 5' flanking regions, resulting from Microprocessor cleavage, are targeted by the RNA exosome in mouse embryonic stem cells (mESCs). This is facilitated by a physical link between DGCR8 and the nuclear exosome targeting (NEXT) component ZCCHC8.
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- Alzheimer's disease (AD) is the leading type of dementia, with genetics linking microglia and neuroimmunity to its development, prompting researchers to use induced pluripotent stem cell (iPSC)-derived microglia for modeling AD.
- The study investigated how iPSC-microglia respond to various immune stimuli (PGE2, LPS+IFN-γ) over 24 and 48 hours through single-cell RNA sequencing, revealing a shared transcriptional response and a potential common mechanism.
- Researchers found significant gene expression overlap with human AD microglia but noted inconsistencies, emphasizing that only certain stimuli (like LPS) elicited a relevant transcriptional response in both mouse and human models.
Background: Lower body lift procedure is one of the most common procedures in postbariatric surgery, which can be followed by postoperative complications that delay the healing time. The purpose of this study was to analyse whether the use of negative pressure wound therapy (NPWT) as a replacement for the classical drainage method would provide better postoperative results with fewer complications.
Methods: The authors reviewed their experience with 46 consecutive patients that underwent lower body lift surgery from 2018 to 2021.
Cell biology, plant-based extracts, structural chemistry, and laboratory in vitro or in vivo experiments are the principal aspects or interfaces that can contribute to discovering new possibilities in cancer therapy and to developing improved chemotherapeutics. Forestry residues can be used for their wealthy resource in polyphenols and other phytoconstituents known for anticancer properties. This review is designed to bring together information on the in vitro or in vivo anticancer potential of woody vascular plants especially the bark extracts (BE) and biosynthesized metallic nanoparticles (BMN) using bark extracts.
View Article and Find Full Text PDFBackground: Childbirth experience could be complicated and even traumatic. This study explored the possible risk factors for post-traumatic stress disorder following childbirth (PTSD-FC) in mothers and partners.
Methods: Through a cross-sectional online survey biographical, medical, psychological, obstetrical and trauma history data were collected.