An in vivo model system for measuring the thrombolytic efficiency of plasminogen activators was used. The formation of radiolabelled microthrombi was induced by infusion with I-125 labelled fibrinogen and thrombin. Reactive fibrinolysis was inhibited by administration of suboptimal levels of e-aminocaproic acid.
View Article and Find Full Text PDFAdult germfree rats excreted 87% more calories with the feces than comparable conventional rats, but this loss was compensated by an 18% higher intake. As a result, energy utilization of germfree and conventional rats was similar (148 and 143 kcal/kg/day, respectively), although the germfree rat metabolized only 71.9% of its dietary intake, versus the conventional rat's 80%.
View Article and Find Full Text PDFGermfree rats and mice fed solid diets have previously been shown to consume less oxygen than their conventional counterparts. Young adult germfree C3H/He mice how serum T3 concentrations comparable to those of conventional mice, but their serum T4 values are 10-15% lower. Fed chemically defined liquid glucose-amino acid diets, germfree C3H mice use 27% more oxygen than comparable germfree mice fed a solid natural ingredient diet, and 12% more than conventional mice fed the solid diet.
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