EHMT2 as a Candidate Gene for an Autosomal Recessive Neurodevelopmental Syndrome.

Neurodevelopmental disorders (NDD) comprise clinical conditions with high genetic heterogeneity and a notable enrichment of genes involved in regulating chromatin structure and function. The EHMT1/2 epigenetic complex plays a crucial role in repression of gene transcription in a highly tissue- and temporal-specific manner. Mutations resulting in heterozygous loss-of-function (LoF) of EHMT1 are implicated in Kleefstra syndrome 1 (KS1).

Respiratory System of the Two-Toed Sloth (Choloepus didactylus): Macroscopic, Histological and Scanning Electron Microscopy Analysis.

Relatively little research has been conducted regarding Choloepus didactylus and studies that have been done have mainly covered physiology and morphology, as well as studies on its respiratory system. The objective of this study was to describe the components of the respiratory system of the two-toed sloth and compare it with other species already described in the literature. For this purpose, eight adult animals were used.

Topography and morphology of the Eira barbara diaphragm.

Background: The diaphragm, the main muscle involved in respiration and one of those responsible for maintaining life, is still little explored in terms of its morphology in wild animals. There are few studies on the anatomy of Eira barbara, a carnivorous mustelid that is a victim of the urbanization process. In order to contribute to the conservation of the species, we described the topography and morphology of the diaphragm, which may be involved in injuries caused by the impacts of human activities.

Mental disorders and related factors in higher education professors working remotely: a correlational study.

Introduction: Recent changes in labor relations and the employment market in university education have posed significant challenges and increased workloads for faculty a situation that has been exacerbated by the global epidemiological status in 2020.

Objectives: To investigate the presence of mental disorders and associated factors in faculty members at a private university in São Paulo, Brazil.

Methods: This is a quantitative, descriptive, exploratory cross-sectional study conducted in June 2021, using online questionnaires to collect social and demographic and lifestyle data, namely, Self-Reporting Questionnaire (SRQ-20) and the Patient Health Questionnaire (PHQ-9).

Topography of the medullary cone of Choloepus didactylus for locoregional anesthesia purposes.

Choloepus didactylus (two-toed sloth) is a Xenarthran mammal whose morphology has so far been little studied. Given the increasing number of sloths requiring clinical and surgical interventions, this lack of clarity regarding anatomical features and landmarks has had a negative impact on veterinary decision-making for this species. We therefore sought to describe the topography of the medullary cone (MC) of Choloepus didactylus in order to provide guidance to qualified professionals on the ideal access for locoregional anesthesia.