Publications by authors named "E Bourogaa"
Objective: To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea (J. phoenicea) berries against CCl-induced oxidative damage in rats.
Methods: Hepatotoxicity was induced in albino Wistar rats by single dose of CCl dissolved in olive oil (1 mL/kg BW, 1/1 in olive oil, i.
In this study, we investigated the protective effects of Peganum harmala seeds extract (CPH) against chronic ethanol treatment. Hepatotoxicity was induced in male Wistar rats by administrating ethanol 35% (4 g/kg/day) for 6 weeks. CPH was co-administered with ethanol, by intraperitonial (IP) injection, at a dose of 10 mg/kg bw/day.
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- - The study investigates the protective effects of a flavonoid-enriched fraction from Hammada scoparia against liver damage caused by ischemia/reperfusion injury during liver surgeries or transplants.
- - Rats were divided into five groups to assess the impact of pharmacological preconditioning and technical postconditioning, revealing that the flavonoid treatment significantly reduced liver injury markers and enhanced antioxidant enzyme levels.
- - The combination of pharmacological preconditioning and postconditioning showed superior effectiveness in minimizing oxidative stress and improving liver morphology compared to using either treatment individually, suggesting its potential as a therapeutic agent for hepatic IRI.
To investigate the molecular mechanism underlying the neuroprotective effect of lithium on cells, in this study, we exposed SH-SY5Y cells to 0.5 mmol/L lithium carbonate (Li2CO2) for 25-50 weeks and then detected the expression levels of some neurobiology related genes and post-translational modifications of stress proteins in SH-SY5Y cells. cDNA arrays showed that pyruvate kinase 2 (PKM2) and calmodulin 3 (CaM 3) expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II (CK2), threonine/tyrosine phosphatase 7 (PYST2), and dopamine beta-hydroxylase (DBH) expression levels were significantly up-regulated.
View Article and Find Full Text PDFThe present work was aimed at studying the antioxidative activity and hepatoprotective effects of methanolic extract (ME) of Hammada scoparia leaves against ethanol-induced liver injury in male rats. The animals were treated daily with 35 % ethanol solution (4 g kg(-1) day(-1)) during 4 weeks. This treatment led to an increase in the lipid peroxidation, a decrease in antioxidative enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in liver, and a considerable increase in the serum levels of aspartate and alanine aminotransferase and alkaline phospahatase.
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