Publications by authors named "E Bourget"
Article Synopsis
- SREB (Super-conserved Receptors Expressed in Brain) is a family of three main orphan G protein-coupled receptors found in most vertebrates, plus an additional novel gene (SREB3B) in some fishes, which are linked to various physiological functions, particularly in reproductive systems.
- The study focused on analyzing the expression patterns of these receptors in the gonads of pufferfish, employing techniques like multiplex RNAscope and absolute qPCR to observe their presence in ovaries and testes.
- Results showed that SREB1 dominated in early ovaries and was also prominent in spermatogonia within early testicular development, with unique expression patterns indicating potential early roles, while SREB3
Technological advancements and rapid expansion in the clinical use of extracorporeal life support (ECLS) across all age ranges in the last decade, including during the COVID-19 pandemic, has led to important ethical considerations. As a costly and resource intensive therapy, ECLS is used emergently under high stakes circumstances where there is often prognostic uncertainty and risk for serious complications. To develop a research agenda to further characterize and address these ethical dilemmas, a working group of specialists in ECLS, critical care, cardiothoracic surgery, palliative care, and bioethics convened at a single pediatric academic institution over the course of 18 months.
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- Family-centered care aims to involve families in a child's critical care, reducing stress and improving communication, with nurses playing a key role in its implementation.
- Nurses conducted interviews to explore their views on the benefits and challenges of this approach in pediatric intensive care units, focusing on environmental factors, stressors, communication issues, and family involvement.
- Findings revealed that nurses perceive family-centered care as beneficial but also highlighted the complexities of adapting to new policies and physical changes in ICUs, which introduced challenges in mentorship and patient safety.
Background: Parents of children admitted to neonatal and pediatric intensive care units (ICUs) are at increased risk of experiencing acute and post-traumatic stress disorder. The integration of palliative care may improve child and family outcomes, yet there remains a lack of information about indicators for specialty-level palliative care involvement in this setting.
Objective: To describe neonatal and pediatric critical care physician perspectives on indicators for when and why to involve palliative care consultants.
Background: Most children die in neonatal and pediatric intensive care units after decisions are made to withhold or withdraw life-sustaining treatments. These decisions can be challenging when there are different views about the child's best interest and when there is a lack of clarity about how best to also consider the interests of the family.
Objective: To understand how neonatal and pediatric critical care physicians balance and integrate the interests of the child and family in decisions about life-sustaining treatments.