Does Cognitive Stimulation Therapy show similar efficacy in individuals with mild-to-moderate dementia from varying etiologies? An examination comparing its effectiveness in Alzheimer's disease and vascular dementia.

Objective: The effectiveness of the Cognitive Stimulation Therapy (CST) is well-documented. Nevertheless, the question of whether specific subgroups of individuals with dementia are more or less likely to benefit from this cognitive stimulation intervention remains unaddressed. Here, we directly compared the effectiveness of the Italian CST (CST-IT), delivered in a previous multicenter controlled clinical trial, across two distinct cohorts of individuals clinically diagnosed with Alzheimer's Disease (AD, = 30) and vascular dementia (VaD, = 27) in the mild-to-moderate stage.

Personal views of aging in midlife and older age: the role of personality.

Introduction: Personal views of aging (VoA) reflect individuals' perceptions, attitudes, and expectations regarding their aging selves. The present cross-sectional study was aimed at examining whether personality traits, as defined by the Big Five model, are associated with different VoA concepts related to both subjective age and awareness of age-related gains and losses in midlife and older age.

Materials And Methods: A sample of 224 participants aged 46-85 years reported their felt age and completed the Awareness of Age-Related Change (AARC) questionnaire, assessing perceptions of age-related gains (AARC-Gains) and losses (AARC-Losses) in various functioning domains, as well as the short version of the Big Five Inventory.

Soft skills and their relationship with life satisfaction and cognitive reserve in adulthood and older age.

Soft skills are key factors for success in multiple contexts of daily life, as well as for life satisfaction, but little is known about their role in late adulthood and older age. In this study, we aimed to investigate the relationships of soft skills, as defined by the World Economic Forum, with two indicators of successful/healthy aging: life satisfaction and cognitive reserve. A sample of 435 adults aged 50 and over completed self-reported measures of soft skills, life satisfaction, and cognitive reserve.

Dose rationale for the use of meropenem/vaborbactam combination in paediatric patients with Gram-negative bacterial infections.

Aims: Meropenem/vaborbactam combination is approved in adults by FDA and EMA for complicated urinary tract infections and by EMA also for other Gram-negative infections. We aimed to characterise the pharmacokinetics of both moieties in an ongoing study in children and use a model-based approach to inform adequate dosing regimens in paediatric patients.

Methods: Over 4196 blood samples of meropenem and vaborbactam (n = 414 subjects) in adults, together with 114 blood samples (n = 39) in paediatric patients aged 3 months to 18 years were available for this analysis.