Publications by authors named "E Bonomi"
Cerebrospinal fluid from frontotemporal dementia patients is toxic to neurons.
Biochim Biophys Acta Mol Basis Dis
June 2021
Frontotemporal Lobar Degeneration (FTD) is a neurodegenerative disease characterized by a progressive deterioration of cognitive functions. Currently, no effective treatment exists. We have studied cytotoxicity and neuronal functionality in cortical and spinal cord cultures upon exposure to cerebrospinal fluid (CSF) from 39 FTD patients.
View Article and Find Full Text PDFBackground: Peri-implant mucositis and peri-implantitis are biofilm-related diseases causing major concern in oral implantology, requiring complex anti-infective procedures or implant removal. Microbial biosurfactants emerged as new anti-biofilm agents for coating implantable devices preserving biocompatibility. This study aimed to assess the efficacy of rhamnolipid biosurfactant R89 (R89BS) to reduce Staphylococcus aureus and Staphylococcus epidermidis biofilm formation on titanium.
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- - This study investigates the progression of biomarkers in progranulin-related frontotemporal dementia (FTD-), highlighting how early changes in language functioning and neurofilament light chain (NfL) can indicate the disease's onset.
- - Researchers included both presymptomatic and symptomatic mutation carriers, analyzing various biomarkers to understand differences between non-fluent variant primary progressive aphasia (nfvPPA) and behavioral variant FTD (bvFTD).
- - Findings suggest that white matter changes occur before grey matter, and the study's model can accurately distinguish presymptomatic from symptomatic carriers, indicating that bvFTD shows more variability in disease progression compared to nfvPPA.
Importance: Behavioral disturbances are core features of frontotemporal dementia (FTD); however, symptom progression across the course of disease is not well characterized in genetic FTD.
Objective: To investigate behavioral symptom frequency and severity and their evolution and progression in different forms of genetic FTD.
Design, Setting, And Participants: This longitudinal cohort study, the international Genetic FTD Initiative (GENFI), was conducted from January 30, 2012, to May 31, 2019, at 23 multicenter specialist tertiary FTD research clinics in the United Kingdom, the Netherlands, Belgium, France, Spain, Portugal, Italy, Germany, Sweden, Finland, and Canada.
Regulation of actin cytoskeleton dynamics in dendritic spines is crucial for learning and memory formation. Hence, defects in the actin cytoskeleton pathways are a biological trait of several brain diseases, including Alzheimer's disease. Here, we describe a novel synaptic mechanism governed by the cyclase-associated protein 2, which is required for structural plasticity phenomena and completely disrupted in Alzheimer's disease.
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