Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.

Parkinson's disease is a progressive neurological disorder, characterized by prominent movement dysfunction. The past two decades have seen a rapid expansion of our understanding of the genetic basis of Parkinson's, initially through the identification of monogenic forms and, more recently, through genome-wide association studies identifying common risk variants. Intriguingly, a number of cellular pathways have emerged from these analysis as playing central roles in the aetiopathogenesis of Parkinson's.

The effect of variable temperature, humidity, and substrate wettability on Gecko (Gekko gecko) locomotor performance and behavior.

Adhesive and locomotor performances of geckos are inherently linked by specialized morphological and biomechanical features. As such, we predict that conditions that lead to poor adhesive performance (i.e.