[Diagnosis and treatment of congenital myopaties].

Important advances have been made in the field of congenital myopathies in recent years, forcing clinicians to constantly review and update this group of diseases. The increasing identification of new genes and phenotypes associated with already known genes has been possible to a great extent thanks to the development accomplished in next generation sequencing techniques, which are increasingly accessible. Knowing better the phenotypic spectrum of these entities allows to establish a phenotype/genotype correlation in some subgroups.

Onset of differentiation is post-transcriptionally controlled in adult neural stem cells.

Whether post-transcriptional regulation of gene expression controls differentiation of stem cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein synthesis, which is key to maintaining the pool of fully functional stem cells, not only in the brain but also in the bone marrow and hair follicles. Neurons also maintain a subset of messenger RNAs in a translationally silent state, which react 'on demand' to intracellular and extracellular signals.

Anatomic basis of notch deformity in open rhinoplasty.

Notch deformity at the columella after the stairstep incision is an unsightly sequel that fuels negativism for open rhinoplasty critics. Obvious causes cited include surgical misadventures involving division of the foot of the medial crus and poor healing. The authors offer yet an additional etiology based on the contraction distortion caused by the depressor septi nasi muscle.

[Chilean nuclear policy].

This official document is statement of the President of the Chilean Nuclear Energy Commission, Dr. Eduardo Bobadilla, about the nuclear policy of the Chilean State, Thanks to the international policy adopted by presidents Aylwin (1990-1994) and his successor Frei Ruiz Tagle (1994-), a nuclear development plan, protected by the Chilean entrance to the nuclear weapons non proliferation treaty and Tlatelolco Denuclearization treaty, has started. Chile will be able to develop without interference, an autonomous nuclear electrical system and other pacific uses of nuclear energy.