Publications by authors named "E Birnie"
Introduction: Randomized controlled trials and meta-analyses have provided evidence of the positive effects of perioperative music interventions on pain, anxiety, and stress. However, the cost-effectiveness is unknown. The objective of this study was to analyze the cost-effectiveness of the implementation of a music intervention in the perioperative care of patients undergoing colorectal surgery.
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- * The study involved a prospective cohort of 611 participants aged 16 and older with at least 5 years of T1D, plus a second group of 160 participants with a minimum of 35 years of T1D, gathering a range of health data, physical assessments, and biological samples.
- * Preliminary findings indicate that additional C-peptide secretion was noted in 10% of individuals, linking fasting C-peptide levels with reduced hypoglycemia awareness
Background: The immunological determinants of delayed viral clearance and intrahost viral evolution that drive the development of new pathogenic virus strains in immunocompromised individuals are unknown. Therefore, we longitudinally studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in relation to viral clearance and evolution in immunocompromised individuals.
Methods: Among Omicron-infected immunocompromised individuals, we determined SARS-CoV-2-specific T- and B-cell responses, anti-spike immunoglobulin G (IgG) and IgG3 titers, neutralization titers, and monoclonal antibody (mAb) resistance-associated mutations.
Peroperative administration of tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce haemorrhage in patients with morbid obesity: protocol for randomised controlled trial (PATRY trial).
BMJ Open
May 2024
Article Synopsis
- The study investigates the effectiveness of tranexamic acid (TXA) in reducing postoperative bleeding in patients undergoing gastric bypass surgery, particularly in the context of Enhanced Recovery After Bariatric Surgery protocols.
- This multicenter, double-blind, randomized controlled trial will involve 1,524 participants across six bariatric centers in the Netherlands, comparing the effects of TXA against a placebo.
- Primary and secondary outcomes will assess hemorrhage rates, surgical details, complications, and costs, with the trial being ethically approved and results planned for publication.
Article Synopsis
- The study aimed to create a framework based on value-based healthcare principles to assess health outcomes and costs on an institutional level, specifically investigating how these factors are related.
- Conducted as a retrospective cohort study at a teaching hospital in Rotterdam, the research involved two populations: bariatric patients (856 total) and breast cancer patients (663 total), analyzing their health outcomes and associated costs of care.
- Results indicated high quality cost indicators (QCI) for both populations, with the bariatric group maintaining stable costs and the breast cancer group showing more variability, while poor health outcomes were linked to increased hospital costs in both groups.