Magneto-mechanical treatment of human glioblastoma cells with engineered iron oxide powder microparticles for triggering apoptosis.

In nanomedicine, treatments based on physical mechanisms are more and more investigated and are promising alternatives for challenging tumor therapy. One of these approaches, called magneto-mechanical treatment, consists in triggering cell death the vibration of anisotropic magnetic particles, under a low frequency magnetic field. In this work, we introduce a new type of easily accessible magnetic microparticles (MMPs) and study the influence of their surface functionalization on their ability to induce such an effect, and its mechanism.

Evidence for internal filtration in the Genius system, performing slow low efficient daily dialysis in the intensive care unit.

Background: Since most intensive care units (ICUs) have no access to high-quality water, the Genius system, using ultrapure water and high-flux dialyzers, might be used during slow low efficient daily dialysis (SLEDD). To get an idea about convective removal, internal filtration (IF) was calculated and compared to other modalities.

Methods: Validated with in vivo measurements, IF was calculated for 8 h Genius SLEDD and 4 h Genius standard dialysis with high-flux dialyzers, and for 8 h SLEDD and 4 h both with standard dialysis machines and low-flux as well as high-flux dialyzers.

Pressure measurement evaluation and accuracy validation: the Gabarith test.

Objective: The dynamic distortion introduced by manometric systems has been known for many years, with several methods developed to describe and quantify the degree of distortion. We developed the Gabarith as a technique to describe more accurately, and yet more simply, the dynamic accuracy of the chain of monitoring.

Setting: A pressure monitoring system transforms some input signal, i.