Publications by authors named "E Bhatia"
Multiple myeloma (MM), a cancer of bone marrow plasma cells, is the second-most common hematological malignancy. However, despite immunotherapies like chimeric antigen receptor (CAR)-T cells, relapse is nearly universal. The bone marrow (BM) microenvironment influences how MM cells survive, proliferate, and resist treatment.
View Article and Find Full Text PDFIntroduction: Parietal cell antibody (PCA)-mediated auto-immune gastritis is known to increase the risk of iron-deficiency and pernicious anaemia in adults with type 1 diabetes mellitus. However, in children and young adults with type 1 diabetes, these data are scarce. We aimed to study the prevalence of parietal cell antibodies (PCAs) and its clinical associations in people with type 1 diabetes with onset below 30 years.
View Article and Find Full Text PDFAims: Islet antibody-negative type 1 diabetes mellitus (T1DM) has not been well characterised. We determined the frequency of antibody-negative T1DM and compared it with antibody-positive T1DM in a cohort of north Indian children.
Methods: In a multi-centre, prospective, observational study, 176 Indian children (age 1-18 years) were assessed within 2 weeks of diagnosis of T1DM.
Article Synopsis
- - Antibodies are generated by naive B cells turning into plasma cells in germinal centers (GCs) of lymphoid tissues, and patients with B cell lymphoma undergoing immunotherapy have reduced antibody production, leading to higher infection rates and weaker vaccine responses.
- - Current research models struggle to effectively mimic long-term GC functions and assess B cell responses, prompting the development of synthetic hydrogels that replicate the lymphoid tissue environment to support human GCs from various blood sources.
- - The new immune organoid systems maintain critical B cell functions longer and offer unique immune programming features; however, they show less effectiveness with lymphoma-derived B cells, indicating a rapid method for studying immune responses and B cell-related disorders.
Article Synopsis
- * Researchers analyzed 58 patients post-surgery for issues like diabetes insipidus and hormone deficiencies, finding that 27.6% experienced transient diabetes insipidus immediately after surgery, with some continuing to have problems six weeks later.
- * Factors like apoplexy and the length of surgery were linked to the likelihood of developing diabetes insipidus, highlighting the need for ongoing follow-up to identify and treat any new hormone deficiencies effectively.