Benefit and risk of heparin for maintaining peripheral venous catheters in neonates: a placebo-controlled trial.

Objectives: Heparin addition to infusion fluids is used to prolong catheter patency in newborns. Heparin may also induce adverse effects such as bleeding complications and immune-mediated heparin-induced thrombocytopenia (HIT). One objective was peripheral venous catheter patency with heparinization of continuous infusions (0.

[Somatic and psychomotor development of children of diabetic mothers in the 4th year in relation to neonatal findings].

340 infants of mothers with type I diabetes (IDM) were examined during the neonatal period for gestational age, somatic data and clinical symptoms of diabetogenic foetopathy and assigned to one of three groups: group I--those whose weight development was delayed or appropriate for gestational age and without symptoms of foetopathy; group II--neonates who were overweight or of appropriate weight for their gestational age and who showed clear symptoms of foetopathy; group III--macrosomic infants (weight and length in advance of gestational age) without any major symptoms of foetopathy. In a pilot study preparing for more comprehensive follow up, 20 children from each group were examined in their fourth year to check their psychomotor and somatic development. To evaluate their growth additional data obtained on IDMs by correspondence were included.

Neonatal jaundice in infants of diabetic mothers.

357 IDMs and 20 healthy newborns of non-diabetic mothers were examined at term for body measurements, red blood cell count, serum bilirubin, cord blood insulin and blood glucose during the first postnatal week. The stage of maternal diabetes did not influence the course of neonatal bilirubin levels, but the IDMs had prolonged and higher bilirubinaemia compared with the controls. Hyperbilirubinaemia was found to be most prominent in newborns with an increased birthweight/length ratio and was not simply related to macrosomia (LGA).

Bilirubin binding and acid-base equilibrium in newborn infants with low birthweight.

Acidosis is known as a risk factor for the development of bilirubin encephalopathy in neonatal jaundice. However, few attempts have been made to evaluate the influence of acid-base state on bilirubin-albumin binding state in blood of newborn infants. Therefore, in 171 appropriate and 83 small for gestational age newborns (birthweight less than 2,500 g) the acid-base state in blood and bilirubin (BR) binding state in serum was measured at the ages of 3, 4, 5, and 8 days.