Publications by authors named "E Beswick"

The World Health Organisation advocates Digital Health Technologies (DHTs) for advancing population health, yet concerns about inequitable outcomes persist. Differences in access and use of DHTs across different demographic groups can contribute to inequities. Academics and policy makers have acknowledged this issue and called for inclusive digital health strategies.

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Background: Digital technology offers individuals the opportunity to monitor their symptoms. Information gathered from apps, devices, and web platforms may be used to direct clinical care and to support research.

Aim: Using this survey, we aim to explore the views of people attending the Anne Rowling Regenerative Neurology Clinic (ARRNC) and their relatives/caregivers regarding the use of digital health technologies to monitor health.

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Article Synopsis
  • - The study analyzed data from the CARE-MND database and the Scottish Regenerative Neurology Tissue Bank to explore the genetic factors and traits associated with motor neuron disease (MND) in a cohort of affected individuals.
  • - Among 339 participants, 13% had identifiable genetic variants linked to MND, with 8.8% having a known C9orf72 repeat expansion, which was linked to poorer cognitive scores.
  • - The findings highlight the importance of early genetic testing for cognitive impairment in MND patients, particularly in Scotland, where certain genetic variants are more prevalent, potentially influencing future treatment strategies.
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Motor neuron disease (MND) is a rapidly progressive condition traditionally assessed using a questionnaire to evaluate physical function, the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R). Its use can be associated with poor sensitivity in detecting subtle changes over time and there is an urgent need for more sensitive and specific outcome measures. The ActiGraph GT9X is a wearable device containing multiple sensors that can be used to provide metrics that represent physical activity.

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Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon. MAIT cells have cytotoxic and pro-inflammatory functions and have potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, including their role in colon cancer, are limited.

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