Publications by authors named "E Berdyshev"
Lipids are important skin components that provide, together with proteins, barrier function of the skin. Keratinocyte terminal differentiation launches unique metabolic changes to lipid metabolism that result in the predominance of ceramides within lipids of the stratum corneum (SC)-the very top portion of the skin. Differentiating keratinocytes form unique ceramides that can be found only in the skin, and generate specialized extracellular structures known as lamellae.
View Article and Find Full Text PDFCERS1 is a biomarker of Staphylococcus aureus abundance and atopic dermatitis severity.
J Allergy Clin Immunol
September 2024
Article Synopsis
- Atopic dermatitis (AD) is an inflammatory skin condition linked to varying levels of Staphylococcus aureus, which affects disease severity and responds to treatments like dupilumab.
- This study aimed to identify host genes related to S aureus levels and AD severity using data from a clinical trial involving 71 adults with moderate-to-severe AD.
- The findings revealed a positive correlation between CERS1 expression (a gene associated with skin lipids) and both S aureus abundance and AD severity, suggesting CERS1 could serve as a biomarker for skin barrier dysfunction, with changes observable after dupilumab treatment.
Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmonary macrophages in response to lipopolysaccharide (LPS). Inhibition of NFATc3 activation by a novel cell-permeable calcineurin peptide inhibitor CNI103 mitigated the development of acute lung injury (ALI) in LPS-treated mice.
View Article and Find Full Text PDFArticle Synopsis
- Immune-related cutaneous adverse events (ircAEs) affect over 50% of patients on checkpoint inhibitors, yet their mechanisms remain unclear.
- A study examined 200 patients (139 with ircAEs and 61 controls) to identify clinical presentations and cytokine responses, leading to the discovery of eight different ircAE phenotypes, such as pruritus and eczema, each involving immune cell infiltration.
- Analysis showed unique cytokine profiles related to specific phenotypes, revealing potential treatment strategies that could involve targeted therapies or corticosteroids for effective management of these adverse events.
Skin biomarkers predict the development of food allergy in early life.
J Allergy Clin Immunol
May 2024
Article Synopsis
- Food allergies (FA) can start in young kids, sometimes linked with skin issues like atopic dermatitis (AD).
- Researchers wanted to find early signs that could predict who might get food allergies later on, by collecting skin samples from newborns.
- They discovered that certain lipids and proteins in the skin of some babies indicated a higher risk for developing food allergies, even before any symptoms showed.