Publications by authors named "E Benson"
Commonly used adenine-induced chronic kidney disease (CKD) murine models often employ C57BL/6 mice; however, this strain has inherent limitations due to its natural resistance to developing key pathological features of CKD, such as tubulointerstitial fibrosis and inflammation. There have been attempts to overcome these barriers by using multiple concentrations of adenine-supplemented diets or by performing prolonged experiments up to 20 weeks. Here, we demonstrate that SKH1 Elite mice develop clinically relevant CKD phenotypes (e.
View Article and Find Full Text PDFKidney physiology shows diurnal variation, and a disrupted circadian rhythm is associated with kidney disease. However, it remains largely unknown whether glomeruli, the filtering units in the kidney, are under circadian control. Here, we investigated core circadian clock components in glomeruli, together with their rhythmic targets and modes of regulation.
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- Atomic layer coating (ALC) is a new, eco-friendly method used to apply a thin ceramic layer to amorphous solid dispersion (ASD) particles, enhancing their characteristics and reducing drug crystallization.
- The study examines how aluminum oxide coatings of different thicknesses affect the release of ritonavir/copovidone ASDs, utilizing confocal fluorescence microscopy (CFM) to observe particle behavior in water.
- Results indicate that while coatings had little effect on dissolution if defects were present, they slowed down hydration and caused issues in drug release from tablets due to gel formation, although combining superdisintegrants with lactose achieved fast release similar to uncoated particles.
Triple negative breast cancer (TNBC) subtype is characterized with higher EMT/stemness properties and immune suppressive tumor microenvironment (TME). Women with advanced TNBC exhibit aggressive disease and have limited treatment options. Although immune suppressive TME is implicated in driving aggressive properties of basal/TNBC subtype and therapy resistance, effectively targeting it remains a challenge.
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- Bats are carriers of deadly zoonotic viruses for humans but seem to tolerate these viruses without becoming ill.
- Jamaican fruit bats (JFBs) produce weaker antibody responses to viruses compared to laboratory mice, yet show greater B cell receptor (BCR) diversity.
- Altering the diet of JFBs by restricting protein can enhance their antibody response to certain viruses, but this improvement comes at the cost of reduced BCR diversity.