Publications by authors named "E Benchimol"
Advancements in the management of pediatric inflammatory bowel disease.
Expert Rev Gastroenterol Hepatol
December 2024
Introduction: The management of pediatric inflammatory bowel disease (PIBD) has drastically changed in the last decade. The limited availability of new biologics or small molecule therapies, and concerns about durability in children has necessitated the development of other advances in management to optimize care.
Areas Covered: This review covers guidance for management targets and advances in optimizing biologic therapies, new medical therapies, adjuvant therapies, precision medicine and mental health concerns in PIBD.
Article Synopsis
- - The study focuses on embedding fullerenes into a chiral environment to create unique materials with applications in chiroptical technology and enantioselective catalysts, as well as understanding chirality-induced spin selectivity (CISS).
- - Researchers designed a chiral Pd2L4 capsule using a special 'ribbon-shaped' ligand derived from Tröger's base naphthalimide, which offers a compact structure with a significant inner cavity for hosting fullerenes.
- - The binding of fullerenes like C60, C70, and corannulenes in acetonitrile results in measurable changes in their optical properties, demonstrating the induction of circular dichroism (CD) that was confirmed through X-ray
Here, we report the synthesis of a family of chiral ZnL tetrahedral cages by subcomponent self-assembly. These cages contain a flexible trialdehyde subcomponent that allows them to adopt stereochemically distinct configurations. The incorporation of enantiopure 1-phenylethylamine produced Δ and Λ enantiopure cages, in contrast to the racemates that resulted from the incorporation of achiral 4-methoxyaniline.
View Article and Find Full Text PDFBackground And Aims: Children with very early onset inflammatory bowel disease (VEO-IBD) are uniquely at risk of inadequate infliximab (IFX) exposure. We studied the association between standard body weight (BW)-based and body surface area (BSA)-based dosing strategies and outcomes.
Methods: We identified VEO-IBD patients treated with IFX before 9 years at a single center.
Article Synopsis
- The study introduces two new structural types in heteroleptic PdAB assemblies: syn-cis-PdAB bowls and cis-PdAB rings that can be bowl-shaped (syn) or saddle-shaped (anti), built upon a common longer fluorenone-based bis-monodentate ligand.
- The size and shape of the rings are influenced by shorter ligands with various para-pyridine donors and aromatic backbones, which affect the assembly's nuclearity through changes in ligand angles and bulk.
- The luminescent properties of the fluorenone ligand are preserved in these assemblies, which can bind chiral guest molecules and generate significant guest-induced circular dichroism (CD) and circularly polarized luminescence (CPL