Publications by authors named "E Benavente"
System Genetics Analysis Reveals Sex Differences in Human Aortic Smooth Muscle Gene Expression.
Bioinform Biol Insights
November 2024
Background: Coronary artery disease (CAD) is one of the leading causes of death worldwide. The buildup of atherosclerotic plaque, including lipids and cellular waste, characterizes this disease. Smooth muscle cells (SMCs) can migrate and proliferate to form a fibrous cap that stabilizes the atherosclerotic plaque in response to plaque buildup.
View Article and Find Full Text PDFMalaria control and elimination efforts would benefit from the identification and validation of new malaria chemotherapeutics. Recently, a transgenic line was used to perform a series of high-throughput in vitro screens for new antimalarials acting against the parasite sexual stages. The screens identified pyrimidine azepine chemotypes with potent activity.
View Article and Find Full Text PDFArticle Synopsis
- Thromboembolic events from advanced atherosclerosis are the main cause of death globally, and lowering lipids through diet and medication is crucial to reduce cardiovascular risks like heart attacks and strokes.
- Researchers fed mice a high-cholesterol diet followed by a zero-cholesterol diet to study the effects of IL-1β treatment on atherosclerotic lesions, using advanced techniques for analysis.
- While lowering lipids improved several health indicators in mice, IL-1β treatment unexpectedly worsened plaque conditions and increased lesion size, indicating a potential risk with this therapy after diet changes.
Article Synopsis
- After a heart attack, fibrotic tissue replaces lost heart muscle, which leads to heart dysfunction, but reprogramming fibroblasts into heart cells using specific transcription factors shows promise for treatment.
- Researchers tested seven compounds, focusing on the effects of small molecules involved in heart cell differentiation, to improve fibroblast reprogramming in both mice and humans.
- Vitamin C was identified as a key enhancer of reprogramming efficiency by reducing reactive oxygen species levels, indicating its antioxidant properties play a crucial role in this process.