Publications by authors named "E Below"
Purpose: Improved survival rates have been observed in castration-resistant prostate cancer (CRPC) due to advancements in treatment options. However, individuals with brain metastases still have limited therapeutic options and an unfavorable prognosis. Therefore, there is an urgent need to explore new therapeutic avenues, such as antibody-drug conjugates (ADCs), which have demonstrated significant clinical activity against active brain metastases in solid tumors.
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- The study investigates the prevalence of NECTIN-4 protein expression in primary tumors and corresponding distant metastases in patients with metastatic urothelial carcinoma (mUC), highlighting its role for the antibody-drug conjugate enfortumab vedotin (EV).
- Results showed that membranous NECTIN-4 expression significantly declines in metastatic spread, with nearly 40% of metastases lacking this expression, suggesting that prior receptor status determination may be necessary before EV treatment.
- The absence or low levels of NECTIN-4 were linked to poorer progression-free survival in patients treated with EV, emphasizing the need to reassess current clinical practices regarding NECTIN-4 receptor testing.
A 17-year-old girl was found vomiting and somnolent at home and was taken to a hospital. The girl initially presented with ventricular tachycardia with broad QRS complexes which was very difficult to control. During the course a subsequent cardiogenic shock developed and despite exhaustion of all therapeutic options the fatal outcome could not be averted.
View Article and Find Full Text PDFThe enzymatic system in saliva, consisting of salivary peroxidase (SPO), hydrogen peroxide (HO), and thiocyanate (SCN), produces hypothiocyanite (OSCN) as a high effective antibacterial compound. OSCN is of great importance for the natural non-specific antibacterial resistance in the oral cavity. However, no analytical method currently exists to selectively quantify OSCN in saliva samples.
View Article and Find Full Text PDFBackground: During hand antisepsis, health care workers (HCWs) are exposed to alcohol by dermal contact and by inhalation. Concerns have been raised that high alcohol absorptions may adversely affect HCWs, particularly certain vulnerable individuals such as pregnant women or individuals with genetic deficiencies of aldehyde dehydrogenase.
Methods: We investigated the kinetics of HCWs' urinary concentrations of ethanol and its metabolite ethyl glucuronide (EtG) during clinical work with and without previous consumption of alcoholic beverages by HCWs.