Short term efficacy and safety in glaucoma patients changed to the latanoprost 0.005%/timolol maleate 0.5% fixed combination from monotherapies and adjunctive therapies.

Aims: To evaluate efficacy and safety in patients with ocular hypertension or open angle glaucoma changed to latanoprost/timolol fixed combination (LTFC).

Methods: A prospective, multicentre, historical control in which qualified patients had their previous therapy substituted by LTFC and were followed for at least 2 months.

Results: In 1676 patients LTFC was continued in 93% throughout the observation period.

Grading of infrared confocal scanning laser tomography and video displays of digitized color slides in exudative age-related macular degeneration.

Purpose: To detect and localize exudative lesions in exudative age-related macular degeneration and to compare images obtained from infrared scanning laser tomography and video displays of digitized color slides in detection and localization of exudation.

Methods: In a prospective study, 11 eyes of 11 patients with exudative age-related macular degeneration were studied. From 32 images with infrared scanning laser tomography, confocal images were chosen in the following focal planes: anterior to the retina, the retinal surface, and the deep retina.

Blue-on-yellow perimetry with a scanning laser ophthalmoscope: small alterations in the central macula with aging.

The sensitivity of short-wavelength-sensitive (SWS) cone pathways was measured in the central fields of 74 normal subjects, aged 17-86 yr, with healthy maculas. The new fundus perimetry technique used a research scanning laser ophthalmoscope with a small entrance pupil to present blue static perimetry targets on a bright yellow background. Simultaneous infrared imaging aided target positioning and rapid assessment of potential pathology in elderly subjects.

Multiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration.

A novel technique, Multiply Scattered Light Tomography (MSLT), and confocal Infrared Imaging are used to provide diagnostic information using a comfortable, rapid, and noninvasive method. We investigated these techniques in detecting neovascularization in age-related macular degeneration. The MSLT used a Vertical Cavity Surface Emitting Laser (VCSEL) at 850 nm, while the confocal imaging technique used either the VCSEL or a 790 nm laser diode.

Scanning laser reflectometry of retinal and subretinal tissues.

Measurements of the human ocular fundus that make use of the light returning through the pupil are called reflectometry. Early reflectometry studies were limited by poor light return from the retina and strong reflections from the anterior surface of the eye. Artifacts produced misleading results in diseases like age-related macular degeneration.