Publications by authors named "E Bassenge"
A number of diseases like hypercholesterolemia and atherosclerosis, hypertension, congestive heart failure, diabetes, ischemia-reperfusion, neurodegenerative diseases as well as acute and chronic inflammatory diseases are characterized by an increased steady-state concentration of reactive oxygen species (ROS). On a biomolecular level an enhanced oxidative stress causes damage of proteins, lipids and nucleic acids. Both the experimental and therapeutic efficiency of different antioxidative compounds (like various antioxidative enzymes) , drugs, metabolites and vitamins for the maintenance of an appropriate intracellular redox potential underline the importance of an excessive ROS-formation for these diseases.
View Article and Find Full Text PDFBackground: To evaluate the effects of the calcium channel blocker lacidipine on vascular responses, such as endothelial function and carotid intima-media thickness (IMT), and on levels of high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease (CAD).
Methods: Endothelial function was assessed by measuring the flow-mediated vasodilation (FMD) of the brachial artery and IMT was measured in the common, bifurcating, and in the internal carotid artery by using high-resolution ultrasound. The study population consisted of 96 consecutive patients [mean age 60 years, male (n) = 70] who showed at least one coronary artery narrowed by more than 50% (coronary angiography).
Background: The primary endpoint of this study was to evaluate the effects of low-dose atorvastatin on carotid intima-media thickness (IMT) and endothelial function, and the secondary endpoint comprised restenosis and target lesion revascularization (TLR) in patients undergoing percutaneous coronary intervention (PCI) with stenting for the treatment of coronary artery disease.
Methods: Two hundred five consecutive patients (mean age, 60 years) undergoing PCI were prospectively randomized to usual therapy (control group, n = 100) or to 10 mg of atorvastatin daily plus usual therapy (statin group, n = 105). Carotid IMT, endothelial function (flow-mediated dilatation [FMD] of the brachial artery), and coronary angiograms were taken before the study and 6 months after randomization.
Background: Endothelial dysfunction is present in patients with coronary artery disease (CAD) or with congestive heart failure.
Hypothesis: This study was performed to evaluate the impact of systolic heart function on endothelial function in patients with CAD.
Methods: The study population consisted of 283 consecutive patients (mean age 59 years, 176 men) undergoing coronary angiography.
Background: The prevalence and clinical significance of atherosclerotic aortic disease have now been documented in a variety of patient populations by use of transesophageal echocardiography (TEE). There are many reports that atherosclerotic aortic plaques detected by TEE are a marker for coronary artery disease (CAD).
Hypothesis: The study was undertaken to evaluate the significance of the intima-media thickness (IMT) and formation of atherosclerotic plaques of the thoracic aorta (TA) in patients with CAD, especially in terms of a correlation between the IMT of the TA and the extent of coronary atherosclerosis.